The stereospecific Z/E isomerization of tetrasubstituted alkenes remains underdeveloped, thus lacking in a stereodivergent synthesis of axially chiral alkenes. Here, authors report the atroposelective synthesis of tetrasubstituted alkene analogues by asymmetric allylic substitution-isomerization, followed by the photocatalyzed Z/E isomerization.

The poisoning of single-atom catalysts hampers their performance. Here, the authors propose Au nanoparticles as an antidote for poisoned Au single-atom catalysts, with trace addition shown to reinforce and sustain propylene epoxidation.

Converting methane to hydrogen and aromatics is a route to upgrading natural gas into high value products. Here the authors report a high-performing synergistic trimetallic thermochemical catalyst, along with mechanistic insights into the process.

Helical protein assemblies are an important biological structure, but are challenging to mimic with synthetic materials. Here, the authors report the use of peptoids to form nanohelix structures with controllable supramolecular chirality.

Reconfigurable neuromorphic transistors are important for creating compact and efficient neuromorphic computing networks. Here, Li et al. introduce an optoelectronic electrolyte-gated transistor to perform multimodal recognition.

The authors show that the influence of the western Indian Ocean on Antarctic sea ice variability in austral spring has been weakening under greenhouse global warming.

It is useful to be able to equip marine animals with sensors, but it can be challenging to attach these to soft marine organisms. Here, the authors use an adhesive hydrogel to achieve rapid attachment of sensors to marine life including jellyfish, squid and lobster.

A pan-Arctic estimate of past and future subsea permafrost including solid Earth effects causes local sea level to differ from the global mean. Future subsea permafrost disappears faster under high than low emissions scenarios.

Little is known about viral communities in deep-sea seamounts. In this study, the authors performed metagenomic and virome analysis from sediments in the western Pacific Ocean and characterize the diversity, distribution and potential ecological roles of viruses in deep-sea seamount sediments.

It is challenging to produce biomass FG continuously due to the lack of an integrated device. Here, we create an integrated automatic system with energy requirement-oriented allocation to achieve continuous biomass FG production with a much lower carbon footprint.

In this study, the authors show that a single dose of a combination of two human-like monoclonal antibodies protect mice in therapeutic treatment against challenges with ectromelia virus and monkeypox virus. Combination treatment provided more effective viral clearance than single antibody treatment.

Functional trade-offs can affect phenotypic variation. Here, the authors examine trade-offs between bite force and speed in 132 carnivore species, finding that optimising for velocity can be obtained in more ways than optimising for force, and this may impact morphological variability.

DNMT3A and DNMT3L form a complex to deposit DNA methylation in mammalian germ cells. Here, the authors report that loss-of-function of ADD domains of DNMT3A and/or DNMT3L has various impacts on DNA methylation landscapes in mouse oocytes and sperm.

The biogenesis of iron-sulfur proteins in eukaryotes is initiated by the mitochondrial core ISC complex. Here, the authors provide structural, biochemical and spectroscopic data to characterize sulfur transfer intermediates in the core ISC complex.

The feasibility and efficacy of neoadjuvant immunotherapy for resectable hepatocellular carcinoma (HCC) have been previously suggested. Here the authors report the results of a phase 1b trial of neoadjuvant tislelizumab plus stereotactic body radiotherapy and adjuvant tislelizumab in early-stage resectable HCC.

Metastatic uveal melanoma is poorly responsive to immune checkpoint inhibition. Here, the authors analyse 100 uveal melanoma metastases using bulk and single cell RNA-seq, TCR analysis, and immune reactivity to show potent, yet, quiescent tumour infiltrating lymphocytes that can be harnessed by adoptive transfer to confer tumour immunity.

The use of bispecific antibodies to target tumour-specific epitopes presented by MHC molecules in tumour tissue is a promising avenue for cancer immunotherapy. Here the authors use a mass-spectrometry guided analysis to identify off-target MHC-peptide complexes that bind to TCR-like antibodies next to the target peptide, enabling a novel approach to monitoring of antibody specificity during clinical maturation and development.

The recent monkeypox outbreak highlighted the need for rapid and accurate diagnosis of this disease. Here, authors develop an ultrasensitive and streamlined CRISPR assay using miniaturized device, which can detect monkeypox virus in rash fluid swab, oral swab, saliva, and urine within 15 minutes.

Here, by using a food digestion model in C. elegans, the authors identify a mechanism by which bacterial peptidoglycan (PGN) interacts with Bacterial Colonization Factor-1 (BCF-1) triggering C. elegans to expand its ability to consume a wide range of foods in their natural environment.

The study introduces a method of integrating gridded estimates of social vulnerability into high-resolution global flood risk maps demonstrating new insights into the geography of flood risk within and between countries.

Collective cooperation is found across many social and biological systems. Here, the authors find that infrequent hub updates promote the emergence of collective cooperation and develop an algorithm that optimises collective cooperation with update rates.

The authors test whether social values have become converged or diverged across national cultures over the last 40 years using a 76-country analysis of the World Values Survey. They show that values have diverged, especially between high-income Western countries and the rest of the world.

This meta-analysis compares the performance of hard, hybrid, soft and natural coastal defence measures. Results show that all measures have a positive economic return over 20 years yet hybrid measures perform best for climate adaptation and mitigation.

Current desalination technologies are energy intensive and suffer from membrane degradation and fouling. Here, authors propose and explore the potential of thermodiffusion as a means of membrane-free, single-phase thermal desalination. A pathway towards a feasible thermodiffusive desalination is provided.