New research from the US has shown that white-tailed deer are being infected with SARS-CoV-2, the virus that causes COVID-19 in humans. Antibodies were found in 40% of deer that were tested from January to March 2021 across Michigan, Pennsylvania, Illinois and New York state. A second unpublished study has detected the virus in 80% of deer sampled in Iowa between November 2020 and January 2021.
Such high levels of infection led the researchers to conclude that deer are actively transmitting the virus to one another. The scientists also identified different SARS-CoV-2 variants, suggesting there have been many human-to-deer infections.
The large numbers of white-tailed deer in North America and the fact that they often live close to people provide several opportunities for the disease to move between the two species. This can include wildlife management operations, field research, recreation, tourism and hunting. In fact, hunters are likely to be one of the most obvious sources of potential reinfection as they regularly handle dead animals. It has also been suggested that water sources contaminated with SARS-CoV-2 might provide a pathway for transmission, although this has yet to be proved.
Human-to-deer and deer-to-deer transmission are believed to be driving the rapid spread of the disease within white-tailed deer populations across the US. This is particularly apparent during the early months of 2021 when COVID infections were spiking in the human population. Previous studies have shown that SARS-CoV-2 can be passed from humans to domestic and captive animals including cats, dogs, zoo animals and, most notably, farmed mink. But, until now, the disease had not been shown to spread in wildlife species.
White-tailed deer are the most abundant large mammal in North America with a range extending from Canada to South America. The US population alone is estimated to number 30 million animals. They are a social species that live in family groups of two to 12 individuals that can thrive in a range of habitats, including urban parks and woodland.
These aspects of their ecology and behaviour have made them a species of particular concern when it comes to the spread of diseases, including bovine tuberculosis and chronic wasting disease. These pathogens have already led to considerable effects on the health of wild and domestic animal populations around the globe.
The findings from these latest studies have raised concerns that white-tailed deer could be a reservoir of SARS-CoV-2. Not only could this readily infect large numbers of animals, but also, more worryingly, it could spill back to humans.
This type of infection cycle was documented in workers on infected mink farms, which ultimately led to the Danish government euthanising their entire captive population of 17 million animals. It is important to underline that there is currently no evidence of SARS-CoV-2 transmission from white-tailed deer to humans. Initial experimental work has also suggests that infected deer tend not to have symptoms. Still, disease transmission in wildlife populations has considerable implications for human and animal health.