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Slime moulds souped up with plant genes churn out drugs
RESEARCH HIGHLIGHT . 17 January 2022 . Slime moulds souped up with plant genes churn out drugs . The amoeba life stage of a common slime mould outshines workhorse microbes at producing certain medicinal compounds. Twitter . Facebook . Email . You have full access to this article via your institution. Download PDF Download PDF The slime mould Dictyostelium discoideum has a vegetative form (above) that can turn into an amoeba form useful for making drugs. Credit: B. Kelly et al./Nature (CC BY 4.0) The amoeba form of a slime mould can be engineered to produce a range of natural, medically useful compounds, including several that are used to treat nerve damage and pain 1 . Scientists have previously used Escherichia coli bacteria and Saccharomyces cerevisiae yeast to create pharmaceutically important molecules known as aromatic polyketides. This required extensive changes to the genomes of E. coli and S. cerevisiae , which do not naturally produce relevant building blocks of polyketides or the enzymes needed to synthesize the compounds. By contrast, the slime mould Dictyostelium discoideum has a host of genes that are useful for producing polyketides, and naturally makes the necessary precursor molecules. It does lack certain enzymes, however, and Falk Hillmann, Vito Valiante and their colleagues at the Hans Kn?ll Institute in Jena, Germany, added plant genes that encode these to the D. discoideum genome, resulting in amoebae that could produce valuable polyketides in a straightforward two-step process. The researchers say that this plant–amoeba hybrid would be suited to mass cultivation and production of drug precursors. Nature 601 , 300 (2022) doi: https://doi.org/10.1038/d41586-022-00067-w References . 1. Reimer, C. et al. Nature Biotechnol . https://doi.org/10.1038/s41587-021-01143-8 (2022). PubMed ? Article ? Google Scholar ? Download references Subjects . Biotechnology . Latest on: . Biotechnology Elizabeth Holmes verdict: researchers share lessons for science . News 04 JAN 22 Ned Seeman (1945–2021) . Obituary 16 DEC 21 Spatial genomics enables multi-modal study of clonal heterogeneity in tissues . Article 15 DEC 21 . Jobs . Postdoctoral fellowship - Genomics of Neurodegeneration . Washington University in St. Louis (WUSTL) Saint Louis, MO, United States Pediatric Metabolic Health Research Faculty . Children's Healthcare of Atlanta (CHOA) Inc. Atlanta, GA, United States Neuroscientist . Cerevance Cambridge, United Kingdom Biologist . NIH National Institute of Environmental Health Sciences (NIEHS) Research Triangle Park, United States .
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