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OSA | Polarization-sensitive imaging with simultaneous bright- and dark-field optical coherence tomography

Accessible Open Access Abstract. Full Article. Figures (6). Equations (1). References (23). Cited By. Back to Top. ?Get PDF . Abstract. We present a polarization-sensitive (PS) extension for bright- and dark-field (BRAD) optical coherence tomography imaging. Using a few-mode fiber detection scheme, the light backscattered at different angles is separated, and the BRAD images of tissue scattering are generated. A calibration method to correct for the fiber birefringence is proposed. Since particle scattering profiles are polarization dependent, a PS detection extends the capabilities for investigating the scattering properties of biological tissues. Both phantoms consisting of different-sized microparticles and a brain tissue specimen were imaged to validate the system performance and demonstrate the complementary image contrast. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Full Article? ? PDF Article OSA Recommended Articles Beyond backscattering: optical neuroimaging by BRAD Pablo Eugui, Antonia Lichtenegger, Marco Augustin, Danielle J. Harper, Martina Muck, Thomas Roetzer, Andreas Wartak, Thomas Konegger, Georg Widhalm, Christoph K. Hitzenberger, Adelheid Woehrer, and Bernhard Baumann Biomed. Opt. Express 9 (6) 2476-2494 (2018) Imaging thermally damaged tissue by polarization sensitive optical coherence tomography Johannes F. de Boer, Shyam M. Srinivas, Arash Malekafzali, Zhongping Chen, and J. Stuart Nelson Opt. Express 3 (6) 212-218 (1998) Effects of sample arm motion in endoscopic polarization-sensitive optical coherence tomography Mark C. Pierce, Milen Shishkov, B. Hyle Park, Nader A. Nassif, Brett E. Bouma, Guillermo J. Tearney, and Johannes F. de Boer Opt. 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Lett. 35, 3489 (2010). [Crossref] . C. Blatter, B. Grajciar, C. M. Eigenwillig, W. Wieser, B. R. Biedermann, R. Huber, and R. A. Leitgeb, Opt. Express 19, 12141 (2011). [Crossref] . A. Wartak, M. Augustin, R. Haindl, F. Beer, M. Salas, M. Laslandes, B. Baumann, M. Pircher, and C. K. Hitzenberger, Biomed. Opt. Express 8, 5560 (2017). [Crossref] . N. Iftimia, B. E. Bouma, and G. J. Tearney, J. Biomed. Opt. 8, 260 (2003). [Crossref] . A. E. Desjardins, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, Opt. Lett. 32, 3158 (2007). [Crossref] . B. Wang, B. Yin, J. Dwelle, H. G. Rylander, M. K. Markey, and T. E. Milner, Opt. Lett. 38, 4374 (2013). [Crossref] . P. Eugui, A. Lichtenegger, M. Augustin, D. J. Harper, M. Muck, T. Roetzer, A. Wartak, T. Konegger, G. Widhalm, C. K. Hitzenberger, A. Woehrer, and B. Baumann, Biomed. Opt. Express 9, 2476 (2018). [Crossref] . H. C. van de Hulst, Light Scattering by Small Particles (Courier Corporation, 1981). . C. E. Saxer, J. F. de Boer, B. H. Park, Y. Zhao, Z. Chen, and J. S. Nelson, Opt. Lett. 25, 1355 (2000). [Crossref] . F. Trevino-Martínez, D. Tentori, C. Ayala-Díaz, and F. J. Mendieta-Jiménez, Opt. Express 13, 2556 (2005). [Crossref] . S. Jiao, W. Yu, G. Stoica, and L. Wang, Opt. Lett. 28, 1206 (2003). [Crossref] . B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, Opt. Express 11, 782 (2003). [Crossref] . B. Baumann, W. Choi, B. Potsaid, D. Huang, J. S. Duker, and J. G. Fujimoto, Opt. Express 20, 10229 (2012). [Crossref] . C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley, 2008). . H. Wang, A. J. Black, J. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, Neuroimage 58, 984 (2011). [Crossref] . Y. Lim, Y.-J. Hong, L. Duan, M. Yamanari, and Y. Yasuno, Opt. Lett. 37, 1958 (2012). [Crossref] . W. Trasischker, S. Zotter, T. Torzicky, B. Baumann, R. Haindl, M. Pircher, and C. K. Hitzenberger, Biomed. Opt. Express 5, 2798 (2014). [Crossref] . N. Lippok, M. Villiger, C. Jun, and B. E. Bouma, Opt. Lett. 40, 2025 (2015). [Crossref] . P.-E. Wolf and G. Maret, Phys. Rev. Lett. 55, 2696 (1985). [Crossref] . N. Vansteenkiste, P. Vignolo, and A. Aspect, J. Opt. Soc. Am. A 10, 2240 (1993). [Crossref] . W. S. Bickel, J. Davidson, D. Huffman, and R. Kilkson, Proc. Natl. Acad. Sci. USA 73, 486 (1976). [Crossref] . 2018 (1). P. Eugui, A. Lichtenegger, M. Augustin, D. J. Harper, M. Muck, T. Roetzer, A. Wartak, T. Konegger, G. Widhalm, C. K. Hitzenberger, A. Woehrer, and B. Baumann, Biomed. Opt. Express 9, 2476 (2018). [Crossref] 2017 (1). A. Wartak, M. Augustin, R. Haindl, F. Beer, M. Salas, M. Laslandes, B. Baumann, M. Pircher, and C. K. Hitzenberger, Biomed. Opt. Express 8, 5560 (2017). [Crossref] 2015 (1). N. Lippok, M. Villiger, C. Jun, and B. E. Bouma, Opt. Lett. 40, 2025 (2015). [Crossref] 2014 (1). W. Trasischker, S. Zotter, T. Torzicky, B. Baumann, R. Haindl, M. Pircher, and C. K. Hitzenberger, Biomed. Opt. Express 5, 2798 (2014). [Crossref] 2013 (2). B. Wang, B. Yin, J. Dwelle, H. G. Rylander, M. K. Markey, and T. E. Milner, Opt. Lett. 38, 4374 (2013). [Crossref] S. L. Jacques, Phys. Med. Biol. 58, R37 (2013). [Crossref] 2012 (2). Y. Lim, Y.-J. Hong, L. Duan, M. Yamanari, and Y. Yasuno, Opt. Lett. 37, 1958 (2012). [Crossref] B. Baumann, W. Choi, B. Potsaid, D. Huang, J. S. Duker, and J. G. Fujimoto, Opt. Express 20, 10229 (2012). [Crossref] 2011 (2). H. Wang, A. J. Black, J. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, Neuroimage 58, 984 (2011). [Crossref] C. Blatter, B. Grajciar, C. M. Eigenwillig, W. Wieser, B. R. Biedermann, R. Huber, and R. A. Leitgeb, Opt. Express 19, 12141 (2011). [Crossref] 2010 (1). M. Villiger, C. Pache, and T. Lasser, Opt. Lett. 35, 3489 (2010). [Crossref] 2007 (1). A. E. Desjardins, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, Opt. Lett. 32, 3158 (2007). [Crossref] 2005 (1). F. Trevino-Martínez, D. Tentori, C. Ayala-Díaz, and F. J. Mendieta-Jiménez, Opt. Express 13, 2556 (2005). [Crossref] 2003 (3). S. Jiao, W. Yu, G. Stoica, and L. Wang, Opt. Lett. 28, 1206 (2003). [Crossref] B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, Opt. Express 11, 782 (2003). [Crossref] N. Iftimia, B. E. Bouma, and G. J. Tearney, J. Biomed. Opt. 8, 260 (2003). [Crossref] 2000 (1). C. E. Saxer, J. F. de Boer, B. H. Park, Y. Zhao, Z. Chen, and J. S. Nelson, Opt. Lett. 25, 1355 (2000). [Crossref] 1993 (1). N. Vansteenkiste, P. Vignolo, and A. Aspect, J. Opt. Soc. Am. A 10, 2240 (1993). [Crossref] 1991 (1). D. Huang, E. Swanson, C. Lin, J. Schuman, W. Stinson, W. Chang, M. Hee, T. Flotte, K. Gregory, and C. Puliafito, Science 254, 1178 (1991). [Crossref] 1985 (1). P.-E. Wolf and G. Maret, Phys. Rev. Lett. 55, 2696 (1985). [Crossref] 1976 (1). W. S. Bickel, J. Davidson, D. Huffman, and R. Kilkson, Proc. Natl. Acad. Sci. USA 73, 486 (1976). [Crossref] Abosch, A.. H. Wang, A. J. Black, J. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, Neuroimage 58, 984 (2011). [Crossref] Akkin, T.. H. Wang, A. J. Black, J. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, Neuroimage 58, 984 (2011). [Crossref] Al-Qaisi, M. K.. H. Wang, A. J. Black, J. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, Neuroimage 58, 984 (2011). [Crossref] Aspect, A.. N. Vansteenkiste, P. Vignolo, and A. Aspect, J. Opt. Soc. Am. A 10, 2240 (1993). [Crossref] Augustin, M.. P. Eugui, A. Lichtenegger, M. Augustin, D. J. Harper, M. Muck, T. Roetzer, A. Wartak, T. Konegger, G. Widhalm, C. K. Hitzenberger, A. Woehrer, and B. Baumann, Biomed. Opt. Express 9, 2476 (2018). [Crossref] A. Wartak, M. Augustin, R. Haindl, F. Beer, M. Salas, M. Laslandes, B. Baumann, M. Pircher, and C. K. Hitzenberger, Biomed. Opt. Express 8, 5560 (2017). [Crossref] Ayala-Díaz, C.. F. Trevino-Martínez, D. Tentori, C. Ayala-Díaz, and F. J. Mendieta-Jiménez, Opt. Express 13, 2556 (2005). [Crossref] Baumann, B.. P. Eugui, A. Lichtenegger, M. Augustin, D. J. Harper, M. Muck, T. Roetzer, A. Wartak, T. Konegger, G. Widhalm, C. K. Hitzenberger, A. Woehrer, and B. Baumann, Biomed. Opt. Express 9, 2476 (2018). [Crossref] A. Wartak, M. Augustin, R. Haindl, F. Beer, M. Salas, M. Laslandes, B. Baumann, M. Pircher, and C. K. Hitzenberger, Biomed. Opt. Express 8, 5560 (2017). [Crossref] W. Trasischker, S. Zotter, T. Torzicky, B. Baumann, R. Haindl, M. Pircher, and C. K. Hitzenberger, Biomed. Opt. Express 5, 2798 (2014). [Crossref] B. Baumann, W. Choi, B. Potsaid, D. Huang, J. S. Duker, and J. G. Fujimoto, Opt. Express 20, 10229 (2012). [Crossref] Beer, F.. A. Wartak, M. Augustin, R. Haindl, F. Beer, M. Salas, M. Laslandes, B. Baumann, M. Pircher, and C. K. Hitzenberger, Biomed. Opt. Express 8, 5560 (2017). [Crossref] Bickel, W. S.. W. S. Bickel, J. Davidson, D. Huffman, and R. Kilkson, Proc. Natl. Acad. Sci. USA 73, 486 (1976). [Crossref] Biedermann, B. R.. C. Blatter, B. Grajciar, C. M. Eigenwillig, W. Wieser, B. R. Biedermann, R. Huber, and R. A. Leitgeb, Opt. Express 19, 12141 (2011). [Crossref] Black, A. J.. H. Wang, A. J. Black, J. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, Neuroimage 58, 984 (2011). [Crossref] Blatter, C.. C. Blatter, B. Grajciar, C. M. Eigenwillig, W. Wieser, B. R. Biedermann, R. Huber, and R. A. Leitgeb, Opt. Express 19, 12141 (2011). [Crossref] Bohren, C. F.. C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley, 2008). Bouma, B. E.. N. Lippok, M. Villiger, C. Jun, and B. E. Bouma, Opt. Lett. 40, 2025 (2015). [Crossref] A. E. Desjardins, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, Opt. Lett. 32, 3158 (2007). [Crossref] N. Iftimia, B. E. Bouma, and G. J. Tearney, J. Biomed. Opt. 8, 260 (2003). [Crossref] Cense, B.. B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, Opt. Express 11, 782 (2003). [Crossref] Chang, W.. D. Huang, E. Swanson, C. Lin, J. Schuman, W. Stinson, W. Chang, M. Hee, T. Flotte, K. Gregory, and C. Puliafito, Science 254, 1178 (1991). [Crossref] Chen, Z.. C. E. Saxer, J. F. de Boer, B. H. Park, Y. Zhao, Z. Chen, and J. S. Nelson, Opt. Lett. 25, 1355 (2000). [Crossref] Choi, W.. B. Baumann, W. Choi, B. Potsaid, D. Huang, J. S. Duker, and J. G. Fujimoto, Opt. Express 20, 10229 (2012). [Crossref] Davidson, J.. W. S. Bickel, J. Davidson, D. Huffman, and R. Kilkson, Proc. Natl. Acad. Sci. USA 73, 486 (1976). [Crossref] de Boer, J. F.. B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, Opt. Express 11, 782 (2003). [Crossref] C. E. Saxer, J. F. de Boer, B. H. Park, Y. Zhao, Z. Chen, and J. S. Nelson, Opt. Lett. 25, 1355 (2000). [Crossref] Desjardins, A. E.. A. E. Desjardins, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, Opt. Lett. 32, 3158 (2007). [Crossref] Duan, L.. Y. Lim, Y.-J. Hong, L. Duan, M. Yamanari, and Y. Yasuno, Opt. Lett. 37, 1958 (2012). [Crossref] Duker, J. S.. B. Baumann, W. Choi, B. Potsaid, D. Huang, J. S. Duker, and J. G. Fujimoto, Opt. Express 20, 10229 (2012). [Crossref] Dwelle, J.. B. Wang, B. Yin, J. Dwelle, H. G. Rylander, M. K. Markey, and T. E. Milner, Opt. Lett. 38, 4374 (2013). [Crossref] Eigenwillig, C. M.. C. Blatter, B. Grajciar, C. M. Eigenwillig, W. Wieser, B. R. Biedermann, R. Huber, and R. A. Leitgeb, Opt. Express 19, 12141 (2011). [Crossref] Eugui, P.. P. Eugui, A. Lichtenegger, M. Augustin, D. J. Harper, M. Muck, T. Roetzer, A. Wartak, T. Konegger, G. Widhalm, C. K. Hitzenberger, A. Woehrer, and B. Baumann, Biomed. Opt. Express 9, 2476 (2018). [Crossref] Flotte, T.. D. Huang, E. Swanson, C. Lin, J. Schuman, W. Stinson, W. Chang, M. Hee, T. Flotte, K. Gregory, and C. Puliafito, Science 254, 1178 (1991). [Crossref] Fujimoto, J. G.. B. Baumann, W. Choi, B. Potsaid, D. Huang, J. S. Duker, and J. G. Fujimoto, Opt. Express 20, 10229 (2012). [Crossref] Grajciar, B.. C. Blatter, B. Grajciar, C. M. Eigenwillig, W. Wieser, B. R. Biedermann, R. Huber, and R. A. Leitgeb, Opt. Express 19, 12141 (2011). [Crossref] Gregory, K.. D. Huang, E. Swanson, C. Lin, J. Schuman, W. Stinson, W. Chang, M. Hee, T. Flotte, K. Gregory, and C. Puliafito, Science 254, 1178 (1991). [Crossref] Haindl, R.. A. Wartak, M. Augustin, R. Haindl, F. Beer, M. Salas, M. Laslandes, B. Baumann, M. Pircher, and C. K. Hitzenberger, Biomed. Opt. Express 8, 5560 (2017). [Crossref] W. Trasischker, S. Zotter, T. Torzicky, B. Baumann, R. Haindl, M. Pircher, and C. K. Hitzenberger, Biomed. Opt. Express 5, 2798 (2014). [Crossref] Harper, D. J.. P. Eugui, A. Lichtenegger, M. Augustin, D. J. Harper, M. Muck, T. Roetzer, A. Wartak, T. Konegger, G. Widhalm, C. K. Hitzenberger, A. Woehrer, and B. Baumann, Biomed. Opt. Express 9, 2476 (2018). [Crossref] Hee, M.. D. Huang, E. Swanson, C. Lin, J. Schuman, W. Stinson, W. Chang, M. Hee, T. Flotte, K. Gregory, and C. Puliafito, Science 254, 1178 (1991). [Crossref] Hitzenberger, C. K.. P. Eugui, A. Lichtenegger, M. Augustin, D. J. Harper, M. Muck, T. Roetzer, A. Wartak, T. Konegger, G. Widhalm, C. K. Hitzenberger, A. Woehrer, and B. Baumann, Biomed. Opt. Express 9, 2476 (2018). [Crossref] A. Wartak, M. Augustin, R. Haindl, F. Beer, M. Salas, M. Laslandes, B. Baumann, M. Pircher, and C. K. Hitzenberger, Biomed. Opt. Express 8, 5560 (2017). [Crossref] W. Trasischker, S. Zotter, T. Torzicky, B. Baumann, R. Haindl, M. Pircher, and C. K. Hitzenberger, Biomed. Opt. Express 5, 2798 (2014). [Crossref] Hong, Y.-J.. Y. Lim, Y.-J. Hong, L. Duan, M. Yamanari, and Y. Yasuno, Opt. Lett. 37, 1958 (2012). [Crossref] Huang, D.. B. Baumann, W. Choi, B. Potsaid, D. Huang, J. S. Duker, and J. G. Fujimoto, Opt. Express 20, 10229 (2012). [Crossref] D. Huang, E. Swanson, C. Lin, J. Schuman, W. Stinson, W. Chang, M. Hee, T. Flotte, K. Gregory, and C. Puliafito, Science 254, 1178 (1991). [Crossref] Huber, R.. C. Blatter, B. Grajciar, C. M. Eigenwillig, W. Wieser, B. R. Biedermann, R. Huber, and R. A. Leitgeb, Opt. Express 19, 12141 (2011). [Crossref] Huffman, D.. W. S. Bickel, J. Davidson, D. Huffman, and R. Kilkson, Proc. Natl. Acad. Sci. USA 73, 486 (1976). [Crossref] Huffman, D. R.. C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley, 2008). Iftimia, N.. N. Iftimia, B. E. Bouma, and G. J. Tearney, J. Biomed. Opt. 8, 260 (2003). [Crossref] Jacques, S. L.. S. L. Jacques, Phys. Med. Biol. 58, R37 (2013). [Crossref] Jiao, S.. S. Jiao, W. Yu, G. Stoica, and L. Wang, Opt. Lett. 28, 1206 (2003). [Crossref] Jun, C.. N. Lippok, M. Villiger, C. Jun, and B. E. Bouma, Opt. Lett. 40, 2025 (2015). [Crossref] Kilkson, R.. W. S. Bickel, J. Davidson, D. Huffman, and R. Kilkson, Proc. Natl. Acad. Sci. USA 73, 486 (1976). [Crossref] Konegger, T.. P. Eugui, A. Lichtenegger, M. Augustin, D. J. Harper, M. Muck, T. Roetzer, A. Wartak, T. Konegger, G. Widhalm, C. K. Hitzenberger, A. Woehrer, and B. Baumann, Biomed. Opt. Express 9, 2476 (2018). [Crossref] Laslandes, M.. A. Wartak, M. Augustin, R. Haindl, F. Beer, M. Salas, M. Laslandes, B. Baumann, M. Pircher, and C. K. Hitzenberger, Biomed. Opt. Express 8, 5560 (2017). [Crossref] Lasser, T.. M. Villiger, C. Pache, and T. Lasser, Opt. Lett. 35, 3489 (2010). [Crossref] Leitgeb, R. A.. C. Blatter, B. Grajciar, C. M. Eigenwillig, W. Wieser, B. R. Biedermann, R. Huber, and R. A. Leitgeb, Opt. Express 19, 12141 (2011). [Crossref] Lichtenegger, A.. P. Eugui, A. Lichtenegger, M. Augustin, D. J. Harper, M. Muck, T. Roetzer, A. Wartak, T. Konegger, G. Widhalm, C. K. Hitzenberger, A. Woehrer, and B. Baumann, Biomed. Opt. Express 9, 2476 (2018). [Crossref] Lim, Y.. Y. Lim, Y.-J. Hong, L. Duan, M. Yamanari, and Y. Yasuno, Opt. Lett. 37, 1958 (2012). [Crossref] Lin, C.. D. Huang, E. Swanson, C. Lin, J. Schuman, W. Stinson, W. Chang, M. Hee, T. Flotte, K. Gregory, and C. Puliafito, Science 254, 1178 (1991). [Crossref] Lippok, N.. N. Lippok, M. Villiger, C. Jun, and B. E. Bouma, Opt. Lett. 40, 2025 (2015). [Crossref] Maret, G.. P.-E. Wolf and G. Maret, Phys. Rev. Lett. 55, 2696 (1985). [Crossref] Markey, M. K.. B. Wang, B. Yin, J. Dwelle, H. G. Rylander, M. K. Markey, and T. E. Milner, Opt. Lett. 38, 4374 (2013). [Crossref] Mendieta-Jiménez, F. J.. F. Trevino-Martínez, D. Tentori, C. Ayala-Díaz, and F. J. Mendieta-Jiménez, Opt. Express 13, 2556 (2005). [Crossref] Milner, T. E.. B. Wang, B. Yin, J. Dwelle, H. G. Rylander, M. K. Markey, and T. E. Milner, Opt. Lett. 38, 4374 (2013). [Crossref] Muck, M.. P. Eugui, A. Lichtenegger, M. Augustin, D. J. Harper, M. Muck, T. Roetzer, A. Wartak, T. Konegger, G. Widhalm, C. K. Hitzenberger, A. Woehrer, and B. Baumann, Biomed. Opt. Express 9, 2476 (2018). [Crossref] Nelson, J. S.. C. E. Saxer, J. F. de Boer, B. H. Park, Y. Zhao, Z. Chen, and J. S. Nelson, Opt. Lett. 25, 1355 (2000). [Crossref] Netoff, T. I.. H. Wang, A. J. Black, J. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, Neuroimage 58, 984 (2011). [Crossref] Pache, C.. M. Villiger, C. Pache, and T. Lasser, Opt. 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P. Eugui, A. Lichtenegger, M. Augustin, D. J. Harper, M. Muck, T. Roetzer, A. Wartak, T. Konegger, G. Widhalm, C. K. Hitzenberger, A. Woehrer, and B. Baumann, Biomed. Opt. Express 9, 2476 (2018). [Crossref] Rylander, H. G.. B. Wang, B. Yin, J. Dwelle, H. G. Rylander, M. K. Markey, and T. E. Milner, Opt. Lett. 38, 4374 (2013). [Crossref] Salas, M.. A. Wartak, M. Augustin, R. Haindl, F. Beer, M. Salas, M. Laslandes, B. Baumann, M. Pircher, and C. K. Hitzenberger, Biomed. Opt. Express 8, 5560 (2017). [Crossref] Saxer, C. E.. C. E. Saxer, J. F. de Boer, B. H. Park, Y. Zhao, Z. Chen, and J. S. Nelson, Opt. Lett. 25, 1355 (2000). [Crossref] Schuman, J.. D. Huang, E. Swanson, C. Lin, J. Schuman, W. Stinson, W. Chang, M. Hee, T. Flotte, K. Gregory, and C. Puliafito, Science 254, 1178 (1991). [Crossref] Stigen, T. W.. H. Wang, A. J. Black, J. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, Neuroimage 58, 984 (2011). [Crossref] Stinson, W.. D. Huang, E. Swanson, C. 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Citing articles from OSA journals and other participating publishers are listed here. Alert me when this article is cited. Click here to see a list of articles that cite this paper Figures (6). Fig. 1. Fig. 2. Fig. 3. Fig. 4. Fig. 5. Fig. 6. Fig. 1. BRAD-OCT setup with PS extension. AOC, analog output card; BD, balanced photodetector; BS, beam splitter; DAQ, data acquisition; FC, fiber collimator; FMF, few-mode fiber; L, lens; MEMS, scanner; PBS, polarizing beam splitter; PC, polarization control paddles; RR, retroreflector; S, sample; SMF, single-mode fiber. Download Full Size PPT Slide PDF Fig. 2. Illustration of the FMF birefringence compensation procedure. (a)?Measured Stokes vectors Sc′ and Sv′ are transformed from the input vectors Sc and Sv due to the FMF birefringence which changes the orientation in the Poincaré sphere. (b)?First rotation R1(θ1) around the normal Sc′×Sc to align Sc′ with Sc. (c)?Second rotation R2(θ2) around the V axis to match the input Stokes vectors orientation. Download Full Size PPT Slide PDF Fig. 3. (a)?Stokes vector image of a birefringent foil for LP01 without calibration. The pixels with low intensity are masked in gray. (b)?Poincaré sphere showing the Stokes vectors as a function of depth indicated in yellow and the pixel indicated in red in (a). (c)?Stokes vector image after the calibration procedure. (d)?Poincaré sphere plotting the cross section in yellow and the pixel in red indicated in (c). Download Full Size PPT Slide PDF Fig. 4. Illustration of phase retardation calculation from the corrected Stokes vectors S′ using the surface Stokes vector Ssurf as reference. Download Full Size PPT Slide PDF Fig. 5. Stokes parameter distributions for phantoms containing (a)?5?μm microspheres reconstructed by LP01, (b)?7?μm microspheres reconstructed by LP01, (c)?5?μm microspheres reconstructed by LP21, and (d)?7?μm microspheres reconstructed by LP21. Download Full Size PPT Slide PDF Fig. 6. PS BRAD-OCT images of a human brainstem. (a)?Intensity B-scan of the LP01 co-polarized channel. (b)?Corresponding LP01 retardation B-scan. Gray matter tissue appears as polarization preserving (yellow arrow), while the white matter appears as birefringent (increasing retardation, red arrow). (c)?En-face projection image of the co-polarized intensity collected by LP01. (d)?En-face projection image of the cross-polarized intensity collected by LP01. The hyperscattering fiber tracts are indicated by the yellow arrows. (e)?En-face projection image of the co-polarized intensity collected by LP21. (f)?En-face projection image of the cross-polarized intensity collected by LP21. (g)?BRAD ratio image of LP01 and LP21 reflectivity signals reveal strong direct backscattering for the indicated fiber tracts. The granular yellow spots correspond to locations where the wet tissue surface created specular reflection artifacts. (h)?Corresponding LP01 retardation map where high retardation values reveal birefringent white matter tracts. The scale bars correspond to 150?μm. Download Full Size PPT Slide PDF Equations (1). Equations on this page are rendered with MathJax. Learn more. (1) δ=arctan(Q2+U2V). .

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