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New technique better assesses exposure of a population to a virus -- ScienceDaily

Science News from research organizations 1 . 2 . New technique better assesses exposure of a population to a virus . Date: November 22, 2021 Source: Penn State Summary: Accurately assessing the exposure of a population to a particular virus is difficult because the tools for doing so do not account for the fact that many viruses comprise multiple circulating strains, or the fact that people can be vaccinated or naturally immune, among other factors. Using influenza as a model, researchers have developed a new technique that overcomes many of these roadblocks, and they say the tool may be useful for better assessments of exposure to a variety of viruses, including the ones that cause COVID-19 and pneumonia. Share: FULL STORY Accurately assessing the exposure of a population to a particular virus is difficult because the tools for doing so do not account for the fact that many viruses comprise multiple circulating strains, or the fact that people can be vaccinated or naturally immune, among other factors. Using influenza as a model, a team of researchers led by Penn State has developed a new technique that overcomes many of these roadblocks, and they say the tool may be useful for better assessments of exposure to a variety of viruses, including the ones that cause COVID-19 and pneumonia. advertisement "Without an accurate picture of a population's exposure to a particular virus, we cannot effectively plan and implement public health interventions," said Maciej Boni, associate professor of biology who led the study. In their study, which appeared on Nov. 18 in the journal Nature Communications , the researchers specifically investigated the attack rate for human influenza A virus in a tropical setting, which comprises two subtypes -- H3N2 and H1N1 -- and multiple strains. According to Boni, an attack rate is an estimate of how many people have been infected with a particular disease, regardless of whether they had symptoms or whether they were tested or not. "Accurately estimating the attack rate of a virus sounds like something epidemiologists should be able to do quite easily," he said, "but there are at least four major complications. First, you need to pre-plan collections of blood samples, otherwise there's no way to get a snapshot of who in the population right now has antibodies and who doesn't. Second, when testing for antibodies, you cannot always differentiate someone who was infected from someone who was vaccinated. Third, antibodies wane, so you may not be able to tell if someone was infected if their antibody levels are low now. Finally, many pathogens circulate as groups of strains or groups of variants, and there may be no laboratory assay to test for general exposure to any of these variants." The team, which included researchers from Vietnam and the Netherlands, created a new method that resolves many of these problems and presents accurate general-population, attack-rate estimates for influenza A virus. To conduct their study, the researchers used a dataset of 24,402 general-population serum -- or blood plasma -- samples collected in central and southern Vietnam between 2009 to 2015 and assayed the samples for antibodies to eleven different strains of human influenza A, including the 1918 pandemic 'Spanish Flu' strain and the 2009 'swine flu' pandemic virus strain, which are within the H1N1 subtype. Next, they used this large set of antibody measurements to derive a 'composite antibody measurement' across both subtypes of influenza and across all the different strains. advertisement "This composite measurement allowed us to more accurately estimate who had been infected by any strain and who hadn't," said Boni. "This gives us a general picture of the disease burden of influenza in the tropical environment of southern and central Vietnam." The team's results suggest that, on average, 26% of the Vietnamese population is exposed to subtype H3N2 influenza every year, and 16% is exposed to subtype H1N1. These exposure rates, Boni said, are somewhat higher than the expected level of influenza exposure in temperate countries, all of which have winter flu seasons, but temperate country data have not yet been analyzed with this new approach. "The future of antibody testing will be to move toward technologically advanced platforms that can test for multiple antibody types in a single blood sample," said Marion Koopmans, co-lead author of the study and head of the Viroscience Department at the Erasmus Medical Centre in the Netherlands. "With a small team, we were able to generate 270,000 antibody measurements in just two years. This is proof that this approach could work at a larger scale. The key synergy that allowed this study to go forward, the team said, was the combination of large pre-planned serum collections, which began in 2009, and a high-throughput microarray platform that allowed for large-scale testing of many different kinds of influenza antibodies. "Pre-planning the serum collections and establishing a large, structured serum bank was the key to this study's success," added Guy Thwaites, director of the Oxford University Clinical Research Unit (OUCRU) in Ho Chi Minh City, Vietnam. "The serum bank that made this work possible has also allowed us to do rapid assessments of H7N9 avian influenza antibodies during the H7N9 outbreaks of April 2013 in China, as well as estimates of tetanus vaccine coverage, chikungunya virus circulation history and more." According to Boni, the next key steps in this 'big data' approach to antibody testing are understanding the dynamics of immune waning. "Our study population had almost zero influenza vaccination," said Boni, "so we were able to use our antibody measurements as true indicators of past influenza infection, but we still need a better understanding of how to distinguish infected individuals from vaccinated individuals and how to include the effects of antibody waning into an analysis like this." Other authors on the paper include Dao Nguyen Vinh, Nguyen Thi Duy Nhat, Nguyen Ha Thao Vy, Tran Thi Nhu Thao, Huynh Thi Phuong, Pham Hong Anh, Tran Minh Quan, Nguyen Thi Le Thanh, and Nguyen Van Vinh Chau, Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme; Marc Choisy, Guy E. Thwaites, and Hannah E. Clapham, Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme and University of Oxford; Erwin de Bruin, Erasmus Medical Centre; Stacy Todd, Liverpool School of Tropical Medicine; Nguyen Thi Nam Lien, Hue Provincial Hospital; Nguyen Thi Hong Ha, Khanh Hoa Provincial Hospital; Tran Thi Kim Hong, Dak Lak General Hospital; Pham Quang Thai, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam; Tran Dang Nguyen, Penn State; and Cameron P. Simmons, Monash University. The Wellcome Trust; British Medical Association; National Health and Medical Research Council of Australia; and Dutch Ministry of Economic Affairs, Agriculture, and Innovation supported this research. make a difference: sponsored opportunity Story Source: Materials provided by Penn State . Original written by Sara LaJeunesse. Note: Content may be edited for style and length. Journal Reference : Dao Nguyen Vinh, Nguyen Thi Duy Nhat, Erwin de Bruin, Nguyen Ha Thao Vy, Tran Thi Nhu Thao, Huynh Thi Phuong, Pham Hong Anh, Stacy Todd, Tran Minh Quan, Nguyen Thi Le Thanh, Nguyen Thi Nam Lien, Nguyen Thi Hong Ha, Tran Thi Kim Hong, Pham Quang Thai, Marc Choisy, Tran Dang Nguyen, Cameron P. Simmons, Guy E. Thwaites, Hannah E. Clapham, Nguyen Van Vinh Chau, Marion Koopmans, Maciej F. Boni. Age-seroprevalence curves for the multi-strain structure of influenza A virus . Nature Communications , 2021; 12 (1) DOI: 10.1038/s41467-021-26948-8 . Cite This Page : MLA . APA . Chicago . Penn State. "New technique better assesses exposure of a population to a virus." ScienceDaily. ScienceDaily, 22 November 2021. . Penn State. (2021, November 22). New technique better assesses exposure of a population to a virus. ScienceDaily . Retrieved November 29, 2021 from www.sciencedaily.com/releases/2021/11/211122135430.htm Penn State. "New technique better assesses exposure of a population to a virus." ScienceDaily. www.sciencedaily.com/releases/2021/11/211122135430.htm (accessed November 29, 2021). RELATED TOPICS Health & Medicine Bird Flu . Influenza . Cold and Flu . Infectious Diseases . Plants & Animals Bird Flu Research . Virology . Horses . Microbes and More . advertisement RELATED TERMS Avian flu . Flu vaccine . Pneumonia . Pandemic . Virus . Rabies . Epstein-Barr virus . Influenza pandemic . 1 . 2 . 3 . 4 . 5 . RELATED STORIES The Original Antigenic Sin: How Childhood Infections Could Shape Pandemics . Feb. 18, 2021 ? 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