Single Cell RNA Sequencing Analysis of Human Kidney Reveals the Presence of ACE2 Receptor: A Potential Pathway of COVID-19 Infection
29 Pages Posted: 2 Mar 2020
Qiyu He
Jinan University - First Affiliated Hospital
Tsz Ngai Mok
Jinan University - First Affiliated Hospital
Abstract
Background: A novel coronavirus called COVID-19, which shared 82% similarity of genome sequence with SARS-CoV, was found in Wuhan in late December of 2019, causing an epidemic outbreak of novel coronavirus-induced pneumonia with dramatically increasing number of cases. Several organs are vulnerable to COVID-19 infection. Acute kidney injury (AKI) was reported in parts of case-studies reporting characteristics of COVID-19 patients. This study aimed at analyzing the potential route of COVID-19 entry and mechanism at cellular level.