Leveraging the immune system to enhance TFR: targeting specific immune functions .Enhancing or restoring immune effector functions may provide a pathway to maintaining and increasing TFR in CML. These approaches may be relatively nonspecific, e.g., IFN therapy, or may target specific immune functions. Here we discuss specific immune effectors including the innate system NKs, DCs, pDCs and their crosstalk, and the adaptive system such as CD8+ CTLs, LAAs, immune checkpoints, B-cells and immun...