Results . The LTR targeted ZFP 362b fused with DNMT3A potently represses HIV-1 expression . To achieve stable transcriptional repression of HIV-1, a vector expressing a recombinant fusion protein, ZFP 362b-DNMT3A (ZD3A), was developed which can localize to the nucleus with the help of an embedded nuclear localization signal (NLS) (Fig.? 1a ). This ZFP is capable of binding to the NF-kB doublet binding site within the LTR promoter of HIV-1 and was fused to a DNA methyl transferase 3 domain...