Results . Deciphering and comparing reprogramming and transformation . We developed a mouse model, entitled repro-transformable, to conditionally induce reprogramming or transformation in the same population of cells (Fig. 1a ). OSKM was selected as the prototypical cocktail of reprogramming4 , 30 , 31 , 32. The cooperation between K-ras G12D and c-Myc was chosen as it triggers MEF transformation18 , 25 , 26. R26 rtTA ;Col1a1 4F2A mice33carrying an in...