Introduction. The ubiquitin-proteasome system (UPS) is the key cellular machinery responsible for maintaining intracellular protein homeostasis1,2. This process is initiated by tagging the target protein with ubiquitin (Ub), which involves sequential interactions and activities of enzymes called E1, E2 and E3, which work together to activate, shuttle and ligate Ub to the target protein, respectively3,4. Targeted protein degradation with the use of PROteolysis TArgeting Chimera (PROTACs) th...