Analysis workflow from POAG and IOP GWAS to causal regulatory mechanisms, genes, pathways, and cell types. a POAG and IOP associations genome-wide (known and modest associations) were tested for enrichment among expression and splicing quantitative trait loci (e/sQTLs) in GTEx tissues and retina compared to permuted null sets of variants matched on confounding factors, using QTLEnrich (one-sided). In cases where enrichment was found, the lower bound number of e/sQTLs in a given tissue, ...