Particle therapy . Research update . Proton minibeams could improve treatment of cancer metastases . 06 Feb 2023 Tami Freeman Dose distributions Proton minibeam radiation therapy plans for (left to right columns) metastases in the temporal lobe, the frontal lobe, the liver and the lung. The planning target volumes is outlined in yellow, organs-at-risk in other colours. (Courtesy: R Ortiz et al Med. Phys. 10.1002/mp.16203) Treating cancer patients with spa...

Particle therapy . Research update . Proton minibeams could improve treatment of cancer metastases . 06 Feb 2023 Tami Freeman Dose distributions Proton minibeam radiation therapy plans for (left to right columns) metastases in the temporal lobe, the frontal lobe, the liver and the lung. The planning target volumes is outlined in yellow, organs-at-risk in other colours. (Courtesy: R Ortiz et al Med. Phys. 10.1002/mp.16203) Treating cancer patients with spa...

Particle therapy . Research update . Proton minibeams could improve treatment of cancer metastases . 06 Feb 2023 Tami Freeman Dose distributions Proton minibeam radiation therapy plans for (left to right columns) metastases in the temporal lobe, the frontal lobe, the liver and the lung. The planning target volumes is outlined in yellow, organs-at-risk in other colours. (Courtesy: R Ortiz et al Med. Phys. 10.1002/mp.16203) Treating cancer patients with spa...

Abstract . Malignant sweat gland tumours are rare, with the most common form being Eccrine porocarcinoma (EP). To investigate the mutational landscape of EP, we performed whole-exome sequencing (WES) on 14 formalin-fixed paraffin-embedded samples of matched primary EP and healthy surrounding tissue. Mutational profiling revealed a high overall median mutation rate. This was attributed to signatures of mutational processes related to ultraviolet (UV) exposure, APOBEC enzyme dysregulation, a...