Fragment selection. A) Location of the site sID βαII (volume representation) at the βTub1-αTub2 interdimer interface of the T 2 R-TTL complex. For simplicity, the RB3 and TTL chains are not shown. The two α- and two β-tubulin monomers in the T 2 R-TTL complex are shown in gray and white ribbon representation, respectively. B) Superimposition of the F04, F36, and F41 binding poses (PDB IDs 5S4O, 5S5K, and 5S5P, respectively). Secondary structure elements of tubulin are labeled in blue. ...