Main . The architecture of complex traits in humans can be fully understood only in the context of history. Present-day Mexico covers seven cultural regions, including much of Mesoamerica, with rich civilizational histories9. Archaeological and anthropological approaches have been used to regionalize Mexico into the north of Mexico, the north of Mesoamerica, the centre, occident and Gulf of Mexico, Oaxaca (referring here to the Oaxaca cultural region) and the Mayan region10(F...