Illustration of extensive PVS burden and results of the cross-ancestry PVS GWAS meta-analysis, MTAG analysis and gene-based test. a, Extensive PVS burden (arrows) in WM (top, WM-PVS), BG (middle, BG-PVS) and hippocampus (bottom, HIP-PVS) on T1-weighted axial magnetic resonance images. b, Circular Manhattan plot. The inner circle corresponds to the cross-ancestry GWAS meta-analyses results, the middle circle to the results of the MTAG analysis and the outer circle to gene-based test results....