Methods . Manufacturing of collagen-based corneal stromal equivalent . We developed a collagen-based corneal stromal substitute, BPCDX. BPCDX was manufactured following principles of good manufacturing practices (GMP), in a Class 5 (according to ISO-14644-1) air quality laminar flow clean-room facility in Link?ping, Sweden by LinkoCare Life Sciences AB. Although the BPCDX is subject to an end-stage sterilization process, substantial efforts are made throughout the manufacturing process ...