Materials and methods . Study design and data source . This observational retrospective study used claims data from BKK insurants (i.e., members of Betriebskrankenkassen , company-based sickness funds), part of the German Statutory Health Insurance (SHI) scheme database covering about 90% of the German population (i.e., 73?million people). The SHI database includes primary and specialty care data linked to hospital data and covers registrations, out- and in-patient care, drug prescrip...