ORIGINAL ARTICLE | Open Access NAT10-mediated ac4C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1 Daojia Miao, Jian Shi, Qingyang Lv, Diaoyi Tan, Chuanyi Zhao, Zhiyong Xiong, Xiaoping Zhang Cancer Communications. 2023 https://doi.org/10.1002/cac2.12523 研究亮点 1. 研究揭示了在肾透明细胞肾癌中,NAT10催化mRNA的ac4C修饰水平显著高于邻近正常组织。 2. 研究明确了ANKZF1作为NAT10的直接功能性靶标,其通过与YWHAE的相互作用,竞争性地抑制YAP1的胞质滞留,从而导致淋巴生成因子的转录激活。 3. ...