Abstract . Objective To characterize the clinical features of children and adolescents hospitalized with SARS-CoV-2 infections and to explore predictors for disease severity. Design Nationwide prospective observational cohort study. Setting Data collected from 169 out of 351 childrens hospitals in Germany between March 18, 2020 and April 30, 2021 and comparison with the Statutory Notification System. Participants 1,501 children and adolescents up to 19 years of age with laboratory con...